S100A12 and congenital non-bullous ichthyosiform erythroderma: The hypothesis that the intestinal mucosa of dogs with CIE contains higher numbers of newly recruited (activated, proinflammatory) MΦ contributing to chronic inflammation [35] and expressing the S100A12 protein [58,61,62], whereas the MΦ population detected on routine histopathology is predominantly mature (anti-inflammatory, tissue-resident anergic) with reduced or absent S100A12 expression [62], is also reasonable in cats.