S100/calgranulin-positive cell counts showed no association with the FCEAI scores in cats with CIE, but more severe diarrhea was associated with higher numbers of lamina propria S100A12+ cells in the colon (ρ = 0.78, p = 0.021). The gene discussed is S100A12; the disease is congenital non-bullous ichthyosiform erythroderma.