In further clinical studies, it is important to evaluate the potential beneficial effect of postprandial hyperglycemia correction with hypoglycemic therapy on ROS production by EAT adipocytes in patients with documented atherosclerosis, regardless of the presence or absence of type 2 diabetes mellitus, as well as to investigate the nature of changes in glucose/insulin metabolism and ROS production by adipocytes under the influence of antioxidant treatment. This evidence concerns the gene INS and diabetes mellitus.