A total of 226 patients stratified based on primary tumor size and hormone receptor status were randomized 1:1 to receive either PF-05280014 or trastuzumab-EU (8 mg/kg loading dose, 6 mg/kg subsequently) in parallel with docetaxel and carboplatin every 3 weeks for a total of six treatment cycles. Here, NR4A1 is linked to neoplasm.