NF1 and acute lymphoblastic leukemia: Additionally, the alterations in the NF1 gene are related to several human highly aggressive malignancies diseases including NF1, glioblastoma [39], melanoma [28], ovarian carcinoma [40], lung cancer [41], cholangiocarcinoma [42], breast cancer [43], lymphoblastic leukemia [28], and other types of tumors [44].