NF1 and central nervous system cancer: Neurofibromin is ubiquitously expressed and is present in most tissues acting as a tumor suppressor protein but most highly in particularly high levels in the central nervous system, including Schwann cells along peripheral nerve trunks, glial cells, oligodendrocytes, astrocytes leukocytes, adrenal medulla, and neurons, which partially explains the predilection for peripheral nerve sheath tumors and gliomas [14].