Similarly, tetra-butyl hydroquinone (tBHQ), a synthetic food preservative and NRF2 activator, and edaravone, a medication used to treat patients with amyotrophic lateral sclerosis, were likewise demonstrated to reduce oxidative stress, attenuate neuronal toxicity and reduce Aβ formation in an NT2N neuronal model of Alzheimer’s Disease [35] and SH-SY5Y neuroblastoma cells [36]. Here, NFE2L2 is linked to early-onset autosomal dominant Alzheimer disease.