Thus, two different chromosomal aberrations mediate oncogenic activation of NFkB-TFs in CTCL—genomic deletion at 10q24 activated NFKB2 via truncation in HUT-78, and amplification at 4q24 resulted in overexpression of NFKB1 in HH. This evidence concerns the gene NFKB2 and primary cutaneous T-cell non-Hodgkin lymphoma.