Conflicting findings concerning Notch signaling pathway involvement have also been reported; for example, PIK3R3 (Phosphoinositide-3-Kinase Regulatory Subunit 3) and AKT3 (AKT Serine/Threonine Kinase 3), two downstream signaling pathway components of NCSTN and Notch, have been found markedly overexpressed both in lesional and perilesional skin of HS patients when compared to control [64]; the levels of these proteins, in addition to NCSTN and Notch, were significantly higher in patients with mild disease when compared to those with moderate and severe HS. This evidence concerns the gene STK3 and histiocytic sarcoma.