MAPK8 and metabolic dysfunction-associated steatohepatitis: The relationship of JNK activation pathway to oxidative stress, lipotoxic stress and cell death, inflammation, and cytokines, fibrogenesis, de novo lipogenesis, lipolysis, lipid oxidation and transport are being studied to determine the mechanistic significant of MAPKs in the development of NASH (Figure 1) [6,16,17,18,19,20].