The lncRNA HOTAIRM1 regulates the expression of the HOXA1 gene by sequestering the epigenetic modifiers and demethylases G9a and EZH2 away from the transcription start site of HOXA1 gene, thus mediating demethylation of histone H3K9 and H3K27, and thus, reducing the DNA methylation of the HOZA1 gene, resulting in GBM cell proliferation, migration, invasion, and inhibiting apoptosis [105]. This evidence concerns the gene HOXA1 and glioblastoma.