Another lncRNA called PRC2 and dead-box helicase 5 (DDX5) associated lncRNA (PRADX) could enhance tumorigenesis in GBM by suppressing the expression of the UBX domain protein 1 (UBXN1) protein which is a negative regulator of NF-κB signaling, thus enhancing NF-κB signaling leading to GBM cell proliferation. The gene discussed is NFKB1; the disease is glioblastoma.