As discussed above, delivery of LNA against miR-21 via multi-valent folate (FA)-conjugated three-way-junction (3WJ)-based RNA nanoparticles (RNP) specifically targeted to miR-21, rescued tumor suppressors including PTEN and program cell death 4 (PDCD4), and induce apoptosis in GBM cells in vitro and in vivo [63]. Here, PDCD4 is linked to glioblastoma.