Mutations in the exons 2, 3, and 4 of the RAS isoforms (mainly KRAS, and less frequently NRAS, and HRAS) and in the codon 600 of the BRAF protein (V600E) are well-known prognostic and predictive biomarkers in colorectal cancer (CRC) [88]. The gene discussed is BRAF; the disease is colorectal carcinoma.