We aimed to investigate two genetic variants, reported as germline mutations [4,5], that could potentially induce somatic mutations in HSCs ensuing CHIP development: the TERT intron 5 rs7705526 variant and the TET2 p.Ile1762Val rs2454206 missense mutation in patients with stable coronary artery disease (CAD). The gene discussed is STUB1; the disease is coronary artery disorder.