In patients with T2DM and symptomatic coronary artery disease, the addition of vildagliptin to ongoing metformin showed better glycemic control, lower inflammatory markers (IL-1β and C reactive protein), higher protective markers (adiponectin and HDL-C), and improved lipid profile compared to glimepiride/metformin therapy [151]. The gene discussed is IL1B; the disease is coronary artery disorder.