A clinical trial performed to evaluate the effects of a potent DPP4 inhibitor (gemigliptin) on kidney injury, albuminuria, and vascular inflammation among patients with diabetic kidney disease demonstrated that biomarkers of vascular calcification and kidney injury were improved significantly in the gemigliptin treatment group compared with the control group and more interesting that no serious adverse events in the gemigliptin treatment group were observed during the study [158]. This evidence concerns the gene DPP4 and diabetic kidney disease.