Although GTS-21 displays inhibitory effects on another nicotinic receptor, α4β2nAChR [62,63], and can have anti-inflammatory effects independent of α7nAChR [64], the usage of α7nAChR knock-out mice clearly demonstrates a beneficial effect of α7nAChR blockade in neonatal excitatory brain injury on PND4. This evidence concerns the gene CHRNA7 and brain injury.