Another study suggested that Nlrp3 inflammasome in oxidative-stress-induced neuroinflammation is associated with AD in that it promotes the maturation of proIL-1 and proIL-18 and that microglial cells are the resident macrophages of the central nervous system (CNS) and are primarily responsible for the immune system of the CNS [19]. Here, NLRP3 is linked to Alzheimer disease.