NPPB and hydrops fetalis: In a rat chronic kidney disease model caused by 5/6 subtotal nephrectomy and DOX-induced dilated cardiomyopathy, empagliflozin treatment (20 mg/kg/day for 60 days) was associated with a lower kidney injury score, decreased myocardial fibrosis, inhibited LV remodeling, and decreased BNP protein level in LV (an indicator of HF/pressure overload).