The IC50 value for CDK2 activity for PHA-767491 of 200 nM [17], compares with 600 and 500 nM for roscovitine and CVT-313, respectively, and PHA-767491 shows this effect on RB-positive cancer cells lines PC3, SW480 and SW620 (Figure 5 and Figure 6). The gene discussed is CDK2; the disease is cancer.