LEP and obesity due to melanocortin 4 receptor deficiency: A general assumption is that, in individuals with obesity, obesity-related or derived metabolic dysfunctions—including alterations in insulin, leptin, and adiponectin homeostasis, and loss of control of other adipokines—combined with cardiorespiratory dysfunction and immune dysregulation to mediate the progression to critical illness and/or diminished treatments effectivity [5].