To summarize, in this work, a cluster of genes previously identified in lung tissue or other related tissues to be involved in the routes of SARS-CoV-2 entry into the human cells (ADAM17 and IFITM3) or the host immunological response against the virus (IL6, CXCL10, CXCL11, IFNE, IFNG, TYK2) were found to be differentially expressed (upregulated) in PBCs from COVID-19 patients at the time of hospital admission as compared with non-infected controls. This evidence concerns the gene TYK2 and COVID-19.