Considering that IL-6 produced by adipocytes and adipose tissue resident macrophages is one of the mediators of obesity-linked adipose tissue chronic inflammation [61], we suggest the increased IL6 gene expression observed in the PBCs of COVID-19 patients with obesity may result from increased expression in excess adipose tissue, which we see reflected in PBCs (though not in the levels of IL-6 that reach systemic circulation). This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.