In the present work, upregulation of the expression of IL6 in PBC did not show a clear relation with ulterior disease severity, yet there was a clear tendency to higher IL-6 circulating levels in those patients which experienced a more severe progression, who, in good concordance with previous reports [60], also had higher circulating levels of C-reactive protein (CRP). The gene discussed is CRP; the disease is primary biliary cholangitis.