Increased ADAM17 gene expression in PBCs depending on COVID-19 severity outcome as observed in this work is in good concordance with previous suggestions that ADAM17 sheddase activity may play a crucial role in the pathogenesis of COVID-19 [35,36], even if a functional role in SARS-CoV-2 entry routes remains unclear [37]. The gene discussed is ADAM17; the disease is COVID-19.