ADAM17 and obesity due to melanocortin 4 receptor deficiency: In fact, when male and female patients were analyzed independently (Supplementary Figure S1), an increase in ADAM17 gene expression in PBC that was grossly proportional to COVID-19 severity and BMI range was evidenced in the males, whereas in the females no significant differences were found between control subjects and COVID-19 patients, nor by COVID-19 severity, or obesity.