Moreover, importantly considering the need to further understand the obesity boosting effect on COVID-19 severe evolution, some of the genes analyzed -ADAM17, IFITM3, IFNE, IL6- were more highly expressed in PBCs of COVID-19 patients with obesity, and for three genes—ADAM17, IFITM3 and CCR2- expression levels were dependent on the patients’ BMI, particularly in males. Here, IFITM3 is linked to obesity due to melanocortin 4 receptor deficiency.