Inhibition of MALT1 proteolytic activity by treatment of PCa cells with the MLT-827 had no effect on IκBα, c-Jun, or Akt phosphorylation again underscoring the dominant role of the scaffold function of MALT1 in CBM-mediated NF-κB and JNK signalling in PCa cells. Here, NFKBIA is linked to posterior cortical atrophy.