UC is a genomically heterogeneous disease [17], with significantly mutated genes and high frequencies of occurrence of several essential pathways regulating chromatin state, cell-cycle regulation, and receptor kinase signaling such as the MAPK, PI3K/AKT, FGFR/RAS, and TP53/RB1/MDM2, RAP1 pathways closely related to tumor progression and tumor evolution. The gene discussed is RB1; the disease is neoplasm.