MTOR and mantle cell lymphoma: Moreover, miR-100 inhibits cell proliferation by targeting mTOR [127], miR-15a/16-1 cluster is downregulated in MCL patients and interferes in cell cycle regulation by CCND1, which is a direct target of these two microRNAs [128] and the miR-29 family also have participation in regulating MCL cell proliferation, regulating cyclins expression [129,130,131].