TNF and prostate carcinoma: Wang et al. demonstrated in prostate cancer cells that overexpression of CK2 resulted in the suppression of apoptosis mediated by Tumor necrosis factor (TNF-α), TRAIL, and Fas-ligand (FasL) in cells responsive to these ligands, whereas downregulation of CK2 resulted in augmentation of apoptosis mediated by these ligands [118].