FOXO3a dysregulation, either by inactivation of the FOXO3a gene or cytoplasmic sequestration of the FOXO3a protein, is widely implicated in cellular proliferation in malignancy of breast, liver, colon, prostate, bladder, and nasopharyngeal cancers [67,68,69] (reviewed in [70]). Here, FOXO3 is linked to nasopharyngeal carcinoma.