This effect was most noticeable in the heightened expression of the anti-apoptosis protein Baculoviral IAP Repeat Containing 3 (BIRC3), of the 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11β2), which inactivates the anti-proliferative effects of glucocorticoid receptor and of the Proheparin-binding EGF-like growth factor (HbEGF), a gene promoting mammary cell proliferation and breast cancer cell growth [90]. The gene discussed is HBEGF; the disease is breast cancer.