CK2 was further implicated in the activation of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2), which plays an important role in maintaining intracellular redox homeostasis, via autophagic degradation of Kelch-like ECH-associated protein 1 (Keap1) and activation of AMPK in human breast cancer cells MCF-7 and human colon cancer cells HCT116 [379]. The gene discussed is KEAP1; the disease is malignant colon neoplasm.