RIO1 methylation reduced the tumor growth and metastasis in a mice model whereas CK2 phosphorylation of RIO1 at Thr410 antagonized Lys411 methylation, stabilized RIO1 and impeded the recruitment of FBXO6 to RIO1 thereby driving colorectal and gastric cancer development [297]. This evidence concerns the gene RIOK1 and gastric cancer.