CUL3 and cancer: Recently it has been demonstrated that the CK2-dependent phosphorylation of PD-L1 at positions Thr285 and Thr290 disrupted PD-L1 binding with speckle-type POZ protein and protected PD-L1 from cullin 3 ubiquitin E3 ligase complex-mediated proteasomal degradation in cancer and dendritic cells (DC).