CK2 is a serine/threonine protein kinase extensively studied in the context of cancer and inflammation [125,133] and it was first identified in relation to HD in studies using HEK293T cells co-expressing NMDA receptors (NR1 and NR2B) and human HTT-138Q where CK2 was seen to be upregulated [129]. This evidence concerns the gene GRIN2B and Huntington disease.