To examine the combined effect of blocking IL17 signaling and the inhibition of centriole duplication on the proliferation of keratinocytes, endogenous IL17RA was knocked down with small interference RNA (siRNA), and centrinone was applied to normal human keratinocyte HaCaT and human squamous-cell carcinoma cell line A431 (Figure 2A). Here, IL17RA is linked to squamous cell carcinoma.