Mutations in T/myeloid MPAL frequently involve the IDH2, WT1, CEBPA DNMT3A, EZH2, PHF6, FLT3, KRAS, NRAS, CDKN2A/B, ETV6, NOTCH1, IL7R, FBXW7, and JAK/STAT signaling proteins. The gene discussed is PHF6; the disease is mixed phenotype acute leukemia.