ZRSR2 and myelodysplastic syndrome: GO analyses of mis-spliced genes in MDS patients with ZRSR2 mutations found that the expression of MAPK pathway members (MAPK1, MAPK3), E2F transcription factors (E2F1, E2F2, E2F3, E2F4, E2F6), RAS guanyl releasing protein (RASGRP1, RASGRP2, RASGRP4), RAF serine/threonine protein kinases (ARAF, BRAF, RAF1), and the tumor-suppressor gene PTEN were mainly affected [35].