Splicing changes associated with SF3B1 mutations have been found in many tumor-related genes, including Neurofibromin 1 (NF1), Dicer 1-ribonuclease III (DICER1), Promyelocytic leukemia protein (PML), Cohesin associated factor A (PDS5A), Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), Protein phosphatase 2 regulatory subunit B’alpha (PPP2R5A), and Bromodomain containing 9 (BRD9) [37,47]. This evidence concerns the gene PML and neoplasm.