In addition, number of β2-ADR positive B cells and IL-10 positive B cells are also highly correlated and IL-10 has been shown to increase after β2-ADR stimulation [29,42].Taken together our results and literature suggests, that B cells in course of arthritis modulate the adrenergic receptor signaling profile to increase anti-inflammatory phenotypes and therefore contribute to the anti-inflammatory role of catecholamines in established CIA. The gene discussed is IL10; the disease is Arthritis.