IGF1R and Alzheimer disease: The top five genes regulated by APP were Igf1r (synaptic LTD) [354], Ptgs2 (endocannabinoid neuronal synapse pathway; neuroinflammation, AD progression) [227,355,356,357], Jun (neuroinflammation, AD progression) [358,359,360,361], Dlg4 (PSD95, synaptogenesis) [362,363] and Syn2 (synaptogenesis) [364] (Figure 18).