In recent years, we have demonstrated that in CF airways during P. aeruginosa infection, increased ER-mitochondria juxtapositions favor an inter-organelle Ca2+ transfer via the Mitochondrial Calcium Uniporter (MCU) complex [161], which further downregulates the autophagy in CF, resulting in an augmented pathogen survival and the worsening of inflammatory responses [155,156]. This evidence concerns the gene MCU and cystic fibrosis.