NLRP3 and cystic fibrosis: The mitochondrial Ca2+-overload in CF cells led to persistent oxidative stress, mitochondrial unfolding protein response (UPR), and NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome activation, which contributed to the disturbance of selective autophagic responses, with detrimental repercussions on the capacity to sequester and eliminate invading pathogens or dysfunctional mitochondria (Figure 3).