Several studies using genetic and pharmacologic approaches demonstrate that netrin-1 can function to promote Adora2b signaling during inflammatory conditions outside of the brain, including acute lung injury [47,128,137,138], inflammatory peritonitis [127], intestinal inflammation [139,140], inflammatory kidney disease [141], corneal wound healing [142], and also myocardial ischemia-reperfusion injury [143]. This evidence concerns the gene ADORA2B and injury.