EZH2 and small cell lung carcinoma: SA-β-gal-positive cells represented <4% of the total A549 and H1299 cell population expressing shLuc compared with >10% and 12% of A549 and H1299 cells, respectively, expressing shEZH2, indicating that EZH2 depletion induced cellular senescence in non–small cell lung cancer cells (Figure 4A).