In particular, it was seen that the presence of a rare missense variant (c.11 G > A-p(arg4Gin)) in the ApoCIII gene along with four other common single nucleotide polymorphisms (SNPs; c.*40 C > G in APOCIII e c.*158 T > C; c.162-43 G > A; c.-3 A > G in ApoA5) were associated with a case of severe hypertriglyceridaemia in an adult patient with ALL after two cycles of therapy with PEG-ASP and steroids [45]. Here, APOC3 is linked to hypertriglyceridemia.