By integrative m6A sequencing, RNA sequencing, ribosome profiling, RNA immunoprecipitation sequencing, and proteomics, our team has recently identified a novel oncogenic epitranscriptome axis of METTL3-m6A-GLUT1-mTORC1 [75] and YTHDF1-m6A-ARHGEF2 [79] in promoting CRC tumorigenesis. Here, YTHDF1 is linked to colorectal carcinoma.