Downregulated pathways in TS cells included the idiopathic pulmonary fibrosis and neuroinflammation signaling pathways (Figure 3B), and downregulated pathways in ReA cells included tumor microenvironment pathways, the role of IL-17F in allergic inflammatory airway diseases, the role of IL-17A in psoriasis, and HMGB1 signaling (Figure 3D). Here, HMGB1 is linked to neoplasm.