GCGR and myocardial infarction: The same study also investigated several signaling pathways and found elevations in IRS and AKT phosphorylation in post-MI mouse hearts following GCGR antagonism as well as reduced p38 MAPK, p70S6K, and mTOR phosphorylation, which the researchers hypothesized to contribute to the enhanced insulin sensitivity and reduced cardiac hypertrophy observed in these animals.