GRN and neuronal ceroid lipofuscinosis: In 2016, a c.900_901dupGT mutation in exon 9 of the GRN gene (p.Ser301Cysfs*61) was identified in a young Portuguese female, originating the third case of NCL due to a homozygous GRN mutation [18], and the first one segregating in a family with confirmed pathology of FTLD [19] (Figure 1).