We posited that CEACAM1 phosphorylation by pulses of released insulin constitutes a main protective mechanism against the higher levels of insulin in the portal vein, not only by mediating hepatic insulin clearance and maintaining the homeostatic level of insulin, but also by binding to FASN and maintaining low fatty acid synthesis in hepatocytes [6], thus preventing hepatic steatosis. This evidence concerns the gene FASN and Hepatic steatosis.