That reduced hepatic CEACAM1 expression plays a key role in diet-induced hepatic insulin resistance and steatosis in addition to disturbed insulin clearance is supported by the reversal of these metabolic abnormalities upon adenoviral-mediated delivery of the wild-type, but not the phosphorylation-defective, mutants of CEACAM1 to the liver of mice at 14 days of a high-fat diet [95]. This evidence concerns the gene INS and steatosis.