Along with increasing amounts of fibrin(ogen), Aß, and Aß-containing fibrin clots in the human AD brain [13,95,96], drastic accumulations of thrombin and prothrombin have been detected in cerebral vessels but also in neurons, glial cells, and intraneural tau deposits of the parenchymal tissue [96,107,108]. The gene discussed is MAPT; the disease is Alzheimer disease.