Moreover, the highest amount of IL15RA transcripts was found in the affected tissue of the two patients who did not survive and from which skin samples were available, suggesting an important role of the stromal cells in the local lymphocyte activation in SJS/TEN through the expression of IL-15Rα, that in turn, would allow IL-15 signaling to responding cells in the affected organ. This evidence concerns the gene IL15RA and toxic epidermal necrolysis.