Charpentier et al. identified MELOE-3, a protein with poor immunogenicity encoded by an additional ORF in the 5′ UTR of meloe and translated by the cap-dependent mechanism, reinforcing the importance of targeting MELOE-1 and MELOE-2 IRES-dependent translation for melanoma immunotherapy [43,55];. The gene discussed is HDAC4-AS2; the disease is melanoma.