In endometriosis, PEA technology identified seven proteins up-regulated (IL-6, IL-8, CCL 19, SCF, VEGF-D, IL-6RA, MIA9) and ten proteins down-regulated (ICOSLG, EGFR, SELE, ErbB2/HER2, IL-6RA, VEGFR-2, Flt3L, CXCL10, HE4, FR-alpha). The gene discussed is ICOSLG; the disease is endometriosis.