APOE and dementia: While the upregulation of miR-195 in the hippocampus restored cognitive function in a chronic brain hypoperfusion model [47], ApoE4+/+KI mice [64], and APP/PS1 transgenic mice [63], the knockdown of endogenous miR-195 by the injection of antogomiR induced dementia in WT rats [47], thereby mimicking the cognitive deficits observed in AD pathology.