In contrast to the KO model, the MR overexpression exacerbated the increase in BP after Ang II infusion; however, IFN-γ-neutralizing antibodies could abolish the deleterious effect, suggesting that IFN-γ produced by infiltrated T cells was a key cytokine link between MR signaling in CD4+ T cells and the resulting hypertension. This evidence concerns the gene IFNG and hypertensive disorder.