NOS2 and early-onset autosomal dominant Alzheimer disease: In this regard, it seems interesting to cite the recent report by Bonfili and colleagues showing that, in the Alzheimer’s disease mouse model, the oral administration with SLAB51 induced the up-regulation in the brain tissue of HIF-1α expression, which in turn was associated with a significant reduction in the expression of inducible nitric oxide synthase (NOS-2) [8].