In this regard, it seems interesting to cite the recent report by Bonfili and colleagues showing that, in the Alzheimer’s disease mouse model, the oral administration with SLAB51 induced the up-regulation in the brain tissue of HIF-1α expression, which in turn was associated with a significant reduction in the expression of inducible nitric oxide synthase (NOS-2) [8]. The gene discussed is NOS2; the disease is Alzheimer disease.