Although a decrease in A2AR expression on PBMCs in CAD [12,13] and the presence of A2AR reserves in ischemia inducible CAD (severe CAD) have been reported in CAD patients [18,19] via the use of a rapid ELISA method, we reported a decrease in soluble A2AR in plasma in patients with inducible ischemia. The gene discussed is ADORA2A; the disease is coronary artery disorder.