LYN and chronic myelogenous leukemia, BCR-ABL1 positive: Given the well-documented pro-survival role of Src and STAT phosphorylation in CML [201], it is interesting, however, that phospho-kinase proteomic profiling of CD34+ cells from chronic-phase CML patients by Ricciardi et al. reported that, in comparison to normal CD34+ cells, leukemic CD34+ progenitor cells exhibited significantly decreased phosphorylation of several Src (Lyn, Lck, and Fyn) and STAT (STAT 2, 5a, 5b, and 6) family kinases and increased phosphorylation of p53 [202].