Through a reverse phase protein array (RPPA), Kornblau and colleagues reported that CD34+CD38− AML LSCs, in comparison to bulk and CD34+ cells, exhibited higher levels of P27, Mcl1, HIF1α, P53, Yap, and phospho-STATs 1, 5, and 6 [155]. This evidence concerns the gene TP53 and acute myeloid leukemia.