Furthermore, transcriptomic profiling has revealed many signaling pathways integral for CML LSC survival, including the TP53-cMYC signaling network [169,170], arachidonate 5-lipoxygenase (Alox5) [171], tyrosine-protein kinase BLK [172], the NFκB pathway [173], the JAK2/STAT5 axis [174,175], the AHI-BCR-ABL-JAK2-DNM2 network [176,177], Wnt activation [178], the proinflammatory transforming growth factor (TGF)-β and tumor-necrosis factor (TNF)-α signaling pathways [179], and integrin-linked kinase signaling [180]. Here, TNF is linked to chronic myelogenous leukemia, BCR-ABL1 positive.