Introduction of a tartrate-resistant acid phosphatase (TRAP)-binding peptide to amphiphilic poly (styrene-alt-maleic anhydride)-b-poly(styrene) (PSMA-b-PS)-based nanoparticles loaded with Micheliolide analog 64 drives precise delivery of drug-loaded nanoparticles to BM and leads to sustained reduction of marrow LSCs in a murine blast crisis CML model [256]. Here, ACP5 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.