Finally, HDAC3 expression and activity increase during hypertrophy [80] whereas a decreased binding of HDAC3 to myofibrils is observed in PE-induced hypertrophy in neonatal rat cardiomyocytes that increases the acetylation of CapZβ1 at lysine 199 and alters myofibril growth during cardiac hypertrophy [34]. Here, HDAC3 is linked to cardiac hypertrophy.