Evaluating the toxicity and antitumor effects of abnormal CBD and its analog O-1602 (which have no or only little affinity for CB1 and CB2), Tomko et al. [24] found that both atypical cannabinoids significantly reduced tumor growth, but concentrations greater than 0.8 mg/L caused higher levels of toxicity to the larvae. Here, CNR1 is linked to neoplasm.