This does not mean that there are no neuronal differences between nop56+/−and adult wild type, especially seeing that genes related to Purkinje cells (grid2), granular cells (cbln12), to balance (zpld1b) and genes that have been related to ALS (c9orf72 and fus) had reduced expression compared to wild type. Here, GRID2 is linked to amyotrophic lateral sclerosis.