In this study, we investigated the effects of n-3 PUFAs on LDL-C and HDL-C subfractions, paraoxonase-1 (PON1) arylesterase activity, serum amyloid A1 (SAA1) levels, and cholesterol efflux capacity (CEC) in a group of patients with genetically verified FH. This evidence concerns the gene SAA1 and familial hyperaldosteronism.