Etanercept [2] and infliximab, inhibitors of proinflammatory cytokine tumor necrosis factor alpha (anti-TNF) [3], were the first anti-TNF biological drugs indicated for rheumatoid arthritis, and later more biological drugs against TNFα were developed, including adalimumab [4], certulizumab pegol [5] and golimumab [6]. This evidence concerns the gene TNF and rheumatoid arthritis.